Kim, J., Koo, B. K. & Knoblich, J. A. Human organoids: model systems for human biology and medicine. Nat. Rev. Mol. Cell Biol. 21, 571–584 (2020).
Google Scholar
Lehmann, R. et al. Human organoids: a new dimension in cell biology. Mol. Biol. Cell 30, 1129–1137 (2019).
Google Scholar
McMahon, A. P. Development of the mammalian kidney. Curr. Top. Dev. Biol. 117, 31–64 (2016).
Google Scholar
Takasato, M. et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564–568 (2015).
Google Scholar
Morizane, R. et al. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat. Biotechnol. 33, 1193–1200 (2015).
Google Scholar
Taguchi, A. & Nishinakamura, R. Higher-order kidney organogenesis from pluripotent stem cells. Cell Stem Cell 21, 730–746 (2017).
Google Scholar
Kuraoka, S. et al. PKD1-dependent renal cystogenesis in human induced pluripotent stem cell-derived ureteric bud/collecting duct organoids. J. Am. Soc. Nephrol. 31, 2355–2371 (2020).
Google Scholar
Zeng, Z. et al. Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat. Commun. 12, 3641 (2021).
Google Scholar
Mae, S. I. et al. Expansion of human ipsc-derived ureteric bud organoids with repeated branching potential. Cell Rep. 32, 107963 (2020).
Google Scholar
Howden, S. E. et al. Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk. Cell Stem Cell 28, 671–684 (2021).
Google Scholar
Bens, M. et al. Corticosteroid-dependent sodium transport in a novel immortalized mouse collecting duct principal cell line. J. Am. Soc. Nephrol. 10, 923–934 (1999).
Google Scholar
Prie, D. et al. Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line. Kidney Int. 47, 1310–1318 (1995).
Google Scholar
Fejes-Toth, G. & Naray-Fejes-Toth, A. Differentiation of renal beta-intercalated cells to alpha-intercalated and principal cells in culture. Proc. Natl Acad. Sci. USA 89, 5487–5491 (1992).
Google Scholar
Qiao, J., Sakurai, H. & Nigam, S. K. Branching morphogenesis independent of mesenchymal–epithelial contact in the developing kidney. Proc. Natl Acad. Sci. USA 96, 7330–7335 (1999).
Google Scholar
Grote, D., Souabni, A., Busslinger, M. & Bouchard, M. Pax 2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133, 53–61 (2006).
Google Scholar
Barak, H., Rosenfelder, L., Schultheiss, T. M. & Reshef, R. Cell fate specification along the anterior-posterior axis of the intermediate mesoderm. Dev. Dyn. 232, 901–914 (2005).
Google Scholar
Loh, K. M. et al. Mapping the pairwise choices leading from pluripotency to human bone, heart, and other mesoderm cell types. Cell 166, 451–467 (2016).
Google Scholar
Ornitz, D. M. & Itoh, N. The fibroblast growth factor signaling pathway. Wiley Interdiscip. Rev. Dev. Biol. 4, 215–266 (2015).
Google Scholar
Perantoni, A. O. et al. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development 132, 3859–3871 (2005).
Google Scholar
Warga, R. M., Mueller, R. L., Ho, R. K. & Kane, D. A. Zebrafish Tbx16 regulates intermediate mesoderm cell fate by attenuating Fgf activity. Dev. Biol. 383, 75–89 (2013).
Google Scholar
Mae, S. I. et al. Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochem. Biophys. Res. Commun. 495, 954–961 (2018).
Google Scholar
Bohnenpoll, T. et al. Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate. Dev. Biol. 380, 25–36 (2013).
Google Scholar
Attia, L., Schneider, J., Yelin, R. & Schultheiss, T. M. Collective cell migration of the nephric duct requires FGF signaling. Dev. Dyn. 244, 157–167 (2015).
Google Scholar
Atsuta, Y. & Takahashi, Y. FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis. Development 142, 2329–2337 (2015).
Google Scholar
Sanchez-Ferras, O. et al. A coordinated progression of progenitor cell states initiates urinary tract development. Nat. Commun. 12, 2627 (2021).
Google Scholar
Pohl, M., Stuart, R. O., Sakurai, H. & Nigam, S. K. Branching morphogenesis during kidney development. Annu. Rev. Physiol. 62, 595–620 (2000).
Google Scholar
Yuri, S., Nishikawa, M., Yanagawa, N., Jo, O. D. & Yanagawa, N. In vitro propagation and branching morphogenesis from single ureteric bud cells. Stem Cell Rep. 8, 401–416 (2017).
Google Scholar
Vega, Q. C., Worby, C. A., Lechner, M. S., Dixon, J. E. & Dressler, G. R. Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc. Natl Acad. Sci. USA 93, 10657–10661 (1996).
Google Scholar
Michos, O. et al. Kidney development in the absence of Gdnf and Spry1 requires Fgf10. PLoS Genet. 6, e1000809 (2010).
Google Scholar
Lu, B. C. et al. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat. Genet. 41, 1295–1302 (2009).
Google Scholar
Bush, K. T. et al. TGF-β superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev. Biol. 266, 285–298 (2004).
Google Scholar
Maeshima, A., Vaughn, D. A., Choi, Y. & Nigam, S. K. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol. 295, 473–485 (2006).
Google Scholar
Michos, O. et al. Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development 134, 2397–2405 (2007).
Google Scholar
Chi, X. et al. Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Dev. Cell 17, 199–209 (2009).
Google Scholar
Costantini, F. GDNF/Ret signaling and renal branching morphogenesis: from mesenchymal signals to epithelial cell behaviors. Organogenesis 6, 252–262 (2010).
Google Scholar
Tsujimoto, H. et al. A modular differentiation system maps multiple human kidney lineages from pluripotent stem cells. Cell Rep. 31, 107476 (2020).
Google Scholar
Uchimura, K., Wu, H., Yoshimura, Y. & Humphreys, B. D. Human pluripotent stem cell-derived kidney organoids with improved collecting duct maturation and injury modeling. Cell Rep. 33, 108514 (2020).
Google Scholar
Unbekandt, M. & Davies, J. A. Dissociation of embryonic kidneys followed by reaggregation allows the formation of renal tissues. Kidney Int. 77, 407–416 (2010).
Google Scholar
Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573–3587 (2021).
Google Scholar
Lake, B. B. et al. An atlas of healthy and injured cell states and niches in the human kidney. Preprint at https://www.biorxiv.org/content/10.1101/2021.07.28.454201v1 (2021).
Kleyman, T. R. & Cragoe, E. J. Jr. Amiloride and its analogs as tools in the study of ion transport. J. Membr. Biol. 105, 1–21 (1988).
Google Scholar
Chen, L., Chou, C. L. & Knepper, M. A. A comprehensive map of mRNAs and their isoforms across All 14 renal tubule segments of mouse. J. Am. Soc. Nephrol. 32, 897–912 (2021).
Werth, M. et al. Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. eLife 6, e24265 (2017).
Google Scholar
Park, J. et al. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science 360, 758–763 (2018).
Google Scholar
Blomqvist, S. R. et al. Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. J. Clin. Invest. 113, 1560–1570 (2004).
Google Scholar
Toka, H. R., Toka, O., Hariri, A. & Nguyen, H. T. Congenital anomalies of kidney and urinary tract. Semin. Nephrol. 30, 374–386 (2010).
Google Scholar
Kuure, S. & Sariola, H. Mouse models of congenital kidney anomalies. Adv. Exp. Med. Biol. 1236, 109–136 (2020).
Google Scholar
Shah, M. M. et al. The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am. J. Physiol. Renal Physiol. 297, F1330–F1341 (2009).
Google Scholar
Schwartz, G. J. et al. Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensin. J. Clin. Invest. 109, 89–99 (2002).
Google Scholar
Schwartz, G. J., Barasch, J. & Al-Awqati, Q. Plasticity of functional epithelial polarity. Nature 318, 368–371 (1985).
Google Scholar
Christensen, B. M. et al. Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI. Am. J. Physiol. Cell Physiol. 286, C952–C964 (2004).
Google Scholar
Davies, J. A., Unbekandt, M., Ineson, J., Lusis, M. & Little, M. H. Dissociation of embryonic kidney followed by re-aggregation as a method for chimeric analysis. Methods Mol. Biol. 886, 135–146 (2012).
Google Scholar
